Long non-coding RNA CASC2 enhances cisplatin sensitivity in oral squamous cell cancer cells by the miR-31-5p/KANK1 axis

Oral squamous cell cancer (OSCC) is a primary malignant tumor of the head and neck. Long non-coding RNA susceptibility candidate 2 (CASC2) related to chemoresistance diverse tumors. At present, resistance OSCC first-line chemotherapy drug cisplatin (DDP) still giant problem. Herein, we investigated role mechanism CASC2 in DDP. Expression levels CASC2, miR-31-5p, KANK1 tissues cells were determined by qRT-PCR. The half-maximal inhibitory concentration (IC50) value DDP-resistant apoptosis via CCK-8 or flow cytometry assays. relationship between miR-31-5p was verified with dual-luciferase reporter RIP vivo confirmed xenograft experiments. We observed that CASC2A downregulated while upregulated (p < 0.05). overexpression enhanced DDP sensitivity accelerated vitro Notably, acted as target for miR-31-5p. Also, modulated expression sponging Both introduction-mediated impacts on restored elevation To conclude, boosted upregulating might be potential treatment.